Neurofibromatosis. (Von Recklinghausen Disease). Genetics, Cell Biology, and Biochemistry. Advances in Neurology. Volume 29
نویسنده
چکیده
Development of Bacterial Infections in Cancer Patients," by Michel P. Glauser and Stephen H. Zinner. The latter chapter reviews systematically the predisposing factors which result in unusual susceptibility. The specific side effects of various cytotoxic agents are discussed, but this section could be enlarged. These chapters would be illuminating to any practitioner faced with treating cancer patients who may have a bacterial infection. As Klastersky points out, it is clearly better to prevent infection than to have to treat it, and his chapter, "Infection Prevention in Cancer Patients," is another outstanding one and well worth the time investment for a busy practitioner. Antibiotic prophylaxis, protected environments, immunoprophylaxis, and granulocyte replacement are all covered (although briefly) in this chapter. I recommend this volume to medical people who want practical information relating to infections in cancer patients. Hematologists, infectious diseases specialists, internists, and pediatricians could all make use of this volume. Hospital and departmental libraries could provide it for those who need a ready reference, while practitioners would want a copy for themselves to peruse at their convenience.
منابع مشابه
Recent progress toward understanding the molecular biology of von Recklinghausen neurofibromatosis.
The gene for von Recklinghausen neurofibromatosis (NF1) was recently identified by positional cloning and found to code for a large, ubiquitously expressed protein. This protein has both structural and functional similarity to a family of proteins with guanosine triphosphatase-activating properties, involved in the regulation of the protooncogene ras. One of the postulated functions of the NF1 ...
متن کاملUnilateral and multiple nodular plexiform Neurofibromas: An uncommon presentation of Neurofibromatosis type 1
Plexiform neurofibroma is a rare variant but pathognomonic of von Recklinghausen disease. We report an uncommon presentation of neurofibromatosis type I in a girl. This 11-year old girl had multiple plexiform neurofibromas on her left hand, and also several Lisch’s nodules. Classification and clinical features are discussed briefly with emphasis on the possibility this condition may not be give...
متن کاملبروز بدخیمی در ضایعات نوروفیبروماتوز در بیمار مبتلا به وون رکلین هاوزن
Neurofibromatosis (Von Recklinghausen syndrome) is an autosomal dominant genetic disease caused by a mutation in the gene expressing neurofibromin. It is characterized by café-au-lait macules, axillary or inguinal freckling, multiple neurofibromas, and developmental delay. Malignant transformation or sarcomatosis may occur in as many as 1.5-15% of patients. Case report: We present a patient wi...
متن کاملLinkage analysis of British and Indian families with Von Recklinghausen neurofibromatosis.
Linkage analysis has been undertaken in two British and three South African Indian families with Von Recklinghausen neurofibromatosis. Eleven polymorphic DNA probes were studied, including both random DNA sequences and candidate oncogenes. Although no evidence for linkage of these probes to the disease was detected, substantial exclusion regions were established on six of the chromosomes studied.
متن کاملVon Recklinghausen neurofibromatosis: a linkage study of candidate and random marker genes.
Genotyping, using plasma proteins or DNA polymorphisms or both, was carried out on 30 families selected through probands with Von Recklinghausen disease. The data provide additional evidence for the exclusion of loci on chromosomes 3 and 5, and chromosome arms 1q, 2p, 4p, 4q, 6q, 7p, 9q, 11p, 11q, and 14q. There was no evidence for genetic heterogeneity at D1S1 (DNF15S2) on chromosome arm 3p, u...
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عنوان ژورنال:
- The Yale Journal of Biology and Medicine
دوره 55 شماره
صفحات -
تاریخ انتشار 1981